Wife :
a) Asai Oeyo (1573-1626) – married in 1595 Tokugawa Hidetada
Asai Nagamasa’s third daughter. Her mother was Oda Oichi younger sister of Oda Nobunaga.
Oeyo's sisters was :
1) Asai Yodo-gimi (Chacha), married with Toyotomi Hideyoshi and mother of Toyotomi Hideyori,
2) Asai Hatsu, wife of the daimyo Kyogoku Takatsugu

b) Children
1) Tokugawa Sen-hime (1597-1666) married a) Toyotomi Hideyori b) Honda Tadatoshi
2) Tokugawa Iemitsu (1604-1651)The third Shogun
3) Tokugawa Tadanaga (1606-1634)
4) Tokugawa Kazuko (Masako) (1607-1678) married Emperor Go-Mizuno-o
5) Tokugawa Tama-hime (1599-1622) married Maeda Toshitsune third Daimyo of Kaga
6) Tokugawa Katsu-hime (1601-1672) married Matsudaira Tadanao
7) A daughter (1602-1630) married with Kyoggoku Tadataka
8) A child (1601-1602)

With other woman
9) Hosina Masayuki (1611-1672) Aizu Matsudaira house ancestor/founder

Adopted child

10) Chiyo-hime (1597-1649) married with Hosokawa Tadatoshi (1586-1641) lord of Kumamoto
11) Kame Hime (1617-1681) = Matsudaira Lord of Echizen
12) Katsu Hime (0000-1678) married whit Ikeda Lord of Tottori